What is GentleFill?

GentleFill is a camera-assisted automated intradermal injection system designed to deliver precise, reproducible wrinkle correction in the superficial dermal layer. It addresses the treatment gap that existing aesthetic modalities cannot reliably reach: etched dermal lines that persist after Botulinum toxin, sit too shallow for conventional dermal fillers, and too deep for laser resurfacing. The device achieves ±10 micrometer depth accuracy, 0.01ml dose precision, and 360° needle control, guided by a 4K real-time camera. It is designed to work with proprietary dermal fillers from filler manufacturers, using a manufacturer-adaptable ampoule architecture and a 510(k)-ready regulatory pathway.

Who invented GentleFill?

GentleFill was invented by Dr. Avraham Amir, MD, a board-certified plastic surgeon and Adjunct Lecturer at Tel Aviv University Faculty of Medicine, with over 30 peer-reviewed international publications and pioneering research experience at the Weizmann Institute of Science. Dr. Amir identified the clinical gap in treating superficial etched dermal lines and developed the precision intradermal delivery system over years of research and device engineering. The company is led by Dr. David Kain, PhD (CEO), who holds a doctorate in Physiology and Pharmacology from Tel Aviv University with 15+ years in drug development and medical device testing. Last updated: May 2026.

What skin conditions does GentleFill treat?

GentleFill specifically targets etched dermal lines — fine wrinkles in the superficial dermal layer that current aesthetic treatments consistently fail to address. Botulinum toxin relaxes muscle-driven wrinkles but does not affect structural dermal lines. Conventional hyaluronic acid fillers are injected too deep to reach this layer precisely. Laser resurfacing addresses surface texture but cannot correct intradermal volume loss. GentleFill fills this anatomical gap by delivering filler at ±10 micrometer depth accuracy directly into the superficial dermis, achieving natural, consistent, reproducible results that no existing single modality can currently match.

How accurate is the GentleFill device?

The GentleFill device achieves ±10 micrometer (±0.01mm) depth accuracy for needle placement, 0.01ml dose precision per injection, and 360° rotational needle control. Real-time 4K camera visualization guides each delivery, eliminating the variability of freehand injection technique. These specifications position GentleFill as a clinical-grade precision instrument rather than a cosmetic tool, enabling reproducible treatment outcomes across different practitioners and patient skin types. The device is designed for integration into existing aesthetic clinic workflows with a 510(k)-ready regulatory pathway for the US market.

Who is on the GentleFill team?

GentleFill is led by Dr. David Kain, PhD, CEO, who holds a doctorate in Physiology and Pharmacology from Tel Aviv University and has 15+ years of experience in drug development and medical device testing with Israeli biotech companies. Mark Shahar serves as CTO, bringing extensive R&D engineering experience and a prior role as CTO of VersaMed, which was acquired by GE. The company was founded by Dr. Avraham Amir, MD. The advisory board includes Dr. Kathy Fields, board-certified dermatologist, Co-Founder of Proactiv Solution and Rodan + Fields Skin Care, and Adjunct Clinical Assistant Professor at Stanford University and UCSF.

Contact: gentlefillbd@gmail.com

Medical Device · Investor Preview

THE FIRST DEVICE
THAT INJECTS
WITH PRECISION.

GentleFill is the world's first camera-assisted automated intradermal delivery platform — eliminating the treatment gap that Botulinum toxin, deep fillers, and resurfacing cannot reach.

Natural eye results
GentleFill device
Device data view
±10μm
Depth Accuracy
0.01ml
Dose Precision
360°
Needle Control
4K
Camera Vision
510(k)
Regulatory Ready
Our Vision

Setting the Clinical
Standard for Precision

To set the clinical standard for precise, safe, intradermal treatment of etched dermal lines — enabling consistent, natural, reproducible results where current modalities fail.

GentleFill is built by a team of plastic surgeons, engineers and medical researchers who share one mission: to bring precision and consistency to intradermal filler delivery. Our expertise spans clinical practice, device engineering and preclinical research.

GentleFill precision aesthetics
The Problem

One Wrinkle Layer Has No Solution

The Real Aesthetic Gap

Wrinkle layer diagram

Etched dermal lines occupy a specific anatomical layer that existing treatments cannot reliably address. They sit too shallow for deep fillers, too deep for resurfacing — and remain after Botulinum toxin.

Persist after Botulinum Toxin
Too shallow for deep fillers
Too deep for resurfacing
Hard to inject manually
Our Solution

Precision Intradermal
Delivery Platform

GentleFill is a compact, camera-assisted intradermal delivery platform engineered to deliver precise and reproducible wrinkle correction in the dermal layer.

01

Controlled Intradermal Depth

In any required depth with accuracy of tens of microns.

02

Micro-Dose Precision

Delivers any dermal filler with unparalleled volumetric accuracy.

03

Multi-Angle Needle Control

Maintains stable alignment along complex wrinkle contours.

04

Uniform Filler Distribution

Consistent results across all treatment areas and patient skin types.

05

Real-Time Visualization

Camera guidance confirms needle position and injection depth live.

06

Pressure Gauge

Delivers only at the precise pressure applied to the skin surface.

GentleFill precision injector device
For Filler Companies

Your Filler.
Our Precision.

Designed to support proprietary dermal fillers with controlled, precise dermal delivery. A strategic partnership that expands your market and elevates your brand.

Low Manufacturing Cost
Manufacturer-adaptable ampoule architecture
Simplified 510(k) Pathway
Regulatory-ready design from day one
High-Volume Production Scalability
Designed for mass-market clinic deployment
Repeat Treatment Model
Drives recurring revenue through consumable cartridges
GentleFill in clinic
The Team

Injectors?
We're Precision Makers.

Dr. Avraham Amir, MD
Founder

Dr. Avraham Amir, MD

Board-certified plastic surgeon with approximately 30 years of extensive clinical experience. Adjunct Lecturer at Tel Aviv University Faculty of Medicine; author of over 30 international publications; pioneering researcher at the Weizmann Institute of Science and inventor of the GentleFill technology.

Dr. David Kain, PhD
CEO

Dr. David Kain, PhD

PhD in Physiology and Pharmacology (Tel Aviv University). Scientific consultant with 15+ years of experience in drug development and medical device testing with Israeli biotech companies.

Mark Shahar
CTO

Mark Shahar

Senior engineer with extensive R&D experience; former CTO at VersaMed (acquired by GE). MSc in Aerospace Engineering and Biomedical Engineering.

Pini Ben-Elazar
Chairman

Pini Ben-Elazar

Results-driven CEO with 25+ years of leadership in healthcare. Led Mor Research for two decades and founded over 80 startups across healthcare and biotech; currently serves as CEO of Laser-Team.

Geva Katz
Mechanical Engineer

Geva Katz

B.Sc. Mechanical Engineering, Ben Gurion University. Co-founder and Head of Mechanics at Skelable. Former Mechanical Developer at Stratasys R&D Center and Chief of Mechanical Workshop, Sayeret Matkal IDF.

Advisory Board

World-Class Guidance

Dr. Kathy Fields
Co-Founder, Proactiv & Rodan + Fields

Dr. Kathy Fields

Adjunct Clinical Assistant Professor · Stanford University · UCSF

Board-certified dermatologist in San Francisco with over three decades of clinical experience. Co-founded two of the most successful skincare brands in the industry — Proactiv Solution and Rodan + Fields Skin Care — bringing innovative treatment solutions to millions worldwide.

She serves as an adviser for emerging technologies that improve patient outcomes, advocating for tools that enable consistent, reproducible results independent of individual operator skill.

Let's Transform
Aesthetic Medicine Together

Join the success.

gentlefillbd@gmail.com
GentleFill© 2026 GentleFill. All rights reserved.
Medical Device · Investor Preview
Medical Device · Investor Preview

THE FIRST
DEVICE THAT

INJECTS WITH
PRECISION.

Camera-assisted intradermal delivery — eliminating the treatment gap that Botulinum toxin, deep fillers, and resurfacing cannot reach.

Scroll
Our Vision

Setting the Clinical
Standard.

To set the clinical standard for precise, safe, intradermal treatment of etched dermal lines — enabling consistent, natural, reproducible results where current modalities fail.

±10μm
Depth Accuracy
0.01ml
Dose Precision
360°
Needle Control
4K
Camera Vision
The Problem
One Wrinkle Layer
Has No Solution

Etched dermal lines occupy a treatment gap that existing modalities cannot address.

01
Persist after Botulinum Toxin
02
Too shallow for deep fillers
03
Too deep for resurfacing
04
Hard to inject manually
Our Solution

Precision Intradermal

Delivery Platform

GentleFill is a compact, camera-assisted intradermal delivery platform engineered for precise and reproducible wrinkle correction in the dermal layer.

±10μm
PRECISION
Controlled Depth
Any required depth with accuracy of tens of microns.
Micro-Dose Precision
Delivers any dermal filler with unparalleled volumetric accuracy.
Multi-Angle Control
Stable alignment along complex wrinkle contours.
Uniform Distribution
Consistent results across all treatment areas and skin types.
Live Visualization
Camera guidance confirms needle position and injection depth.
Pressure Gauge
Delivers only at precise skin-surface pressure.
For Filler Companies
Your Filler.
Our Precision.

Designed to support proprietary dermal fillers with controlled, precise dermal delivery.

Low Manufacturing Cost
Manufacturer-adaptable ampoule architecture
Simplified 510(k) Pathway
Regulatory-ready design from day one
High-Volume Scalability
Designed for mass-market clinic deployment
Repeat Treatment Model
Recurring revenue through consumable cartridges
The Team

Injectors?
We're Precision Makers.

Dr. Avraham Amir, MD
Founder
Dr. Avraham Amir, MD
Board-certified plastic surgeon with ~30 years clinical experience. Adjunct Lecturer at Tel Aviv University; 30+ international publications; researcher at the Weizmann Institute and inventor of GentleFill.
Dr. David Kain, PhD
CEO
Dr. David Kain, PhD
PhD in Physiology & Pharmacology (TAU). 15+ years consulting in drug development and medical device testing with Israeli biotech companies.
Mark Shahar
CTO
Mark Shahar
Senior R&D engineer; former CTO at VersaMed (acquired by GE). MSc in Aerospace Engineering and Biomedical Engineering.
Pini Ben-Elazar
Chairman
Pini Ben-Elazar
CEO with 25+ years in healthcare leadership. Led Mor Research for two decades; founded 80+ startups in healthcare and biotech.
Geva Katz
Mechanical Engineer
Geva Katz
B.Sc. Mechanical Engineering, BGU. Co-founder at Skelable. Former R&D developer at Stratasys; Chief of Mechanical Workshop, Sayeret Matkal IDF.
Advisory Board

World-Class
Guidance

Dr. Kathy Fields
Co-Founder, Proactiv & Rodan + Fields
Dr. Kathy Fields
Adjunct Clinical Assistant Professor · Stanford · UCSF

Board-certified dermatologist with 30+ years of experience. Co-founded Proactiv Solution and Rodan + Fields Skin Care — bringing innovative treatment to millions worldwide.

Join Us

Let's Transform
Aesthetic Medicine
Together

Join the success. Connect with us today.

gentlefillbd@gmail.com
GentleFill
© 2026 GentleFill. All rights reserved.